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Tuesday, August 11, 2009

Newer drugs for Epilepsy

Lacosamide

Lacosamide is an amino acid-related compound that has been studied in both pain syndromes and partial seizures.

Mechanism of Action: Lacosamide enhances slow inactivation of voltage-gated Na+ channels. It also binds to the collapsin-response mediator protein, CRMP-2, thereby blocking the effect of neurotrophic factors such as BDNF and NT3 on axonal and dendritic growth.

Rufinamide

Rufinamide is a new triazole derivative with little similarity to other antiseizure drugs. It is approved for use in Lennox-Gastaut syndrome and preliminary evidence suggests that it may also be useful in other difficult-to-treat epilepsy syndromes.

1 comment:

  1. there are some few more i guess sir.

    retigabine: activates neuronal potassium channel
    esclicarbamazepine:derivative of CBZ
    Carisbamate: derivative of felbamate
    Brivaracetam: Increase selEctivity for protein 2A

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