Antimicrobial activity of Black Cumin seeds (Nigella sativa) against multidrug resistant strains of Coagulase negative Staphylococci.

Salman, Mohd Tariq; Khan, Rahat Ali and Shukla, Indu (2008) Antimicrobial activity of Black Cumin seeds (Nigella sativa) against multidrug resistant strains of Coagulase negative Staphylococci. Hippocratic Journal of Unani Medicine, 3 (1). pp. 107-115

.Nigella sativa (black cumin) seed oil and methanolic extract were tested in varying dilutions against strains of Staphylococcus epidermidis and other coagulase-negative staphylococci resistant to a number of clinically used antibiotics isolated from patients attending JN Medical College Hospital, Aligarh, using disc agar diffusion technique on inoculated Muellar Hinton agar plates under standard laboratory conditions. Both the oil and extract showed remarkable dose dependent antibacterial activity against the tested strains upto a dilution of 1:50 as evident from the zones of inhibition. No cross resistance was noticed with any of the tested antibiotics. To the best of our knowledge, the activity of N. sativa against multidrug resistant clinical strains of Coagulase negative staphylococci is being reported for the first time.
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