Drugs Licensed in 2008 With Mechanisms Similar to Previously Approved Drugs

Generic Name	Brand Name	Pharmacology	2008 FDA Approved Indication	Pharmacologically Similar Agents	11th Edition Reference
bendamustine	Treanda	alkylating agent	Treatment of chronic lymphocytic leukemia	busulfan, carmustine, chlorambucil, cyclophosphamide, ifosfamide, melphalan	pages 1322-1327
certolizumab	Cimzia	tumor necrosis factor inhibitor	Management of Chron's disease	infliximab	page 1419
clevidipine	Cleviprex	dihydropyridine calcium channel antagonist	Treatment of hypertension	amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine nisoldipine	pages 832-838, 857-858
degarelix	none	GnRH receptor antagonist	Treatment of prostate cancer	goserelin, histrelin, leuprolide, triptorelin	pages 1387-1388
desvenlafaxine (major metabolite of venlafaxine)	Pristiq	selective serotonin and norepinephrine reuptake inhibitor	Treatment of major depressive disorder	venlafaxine	pages 434t, 437t, 439t, 444t,
difluprednate	Durezol	opthalmic corticosteroid	Treatment of ocular inflammation	prednisolone	pages 1724-1725
ethinyl estradiol/levonorgestrel	LoSeasonique	oral contraceptive	Prevention of pregnancy	ethinyl estradiol/levonorgestrel (Seasonique)	pages 1563-1567
etravirine	Intelence	non-nucleoside reverse transcriptase inhibitor	Treatment of HIV-1 infection	delavridine, efavirenz, nevirapine	pages 1292-1297
fesoterodine	Toviaz	muscarinic receptor antagonist	Treatment of overactive bladder	darifenacin, solifenacin, tolterodine	pages 173-174
fosaprepitant (produrg of aprepitant)	Emend	substance P/neurokinin 1 receptor antagonist	Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy	aprepitant	pages 1005
fospropofol (produrg of propofol)	Lusedra	sedative-hypnotic	Monitored anesthesia care sedation	propofol	pages 350-351
gadofosveset	Vasovist	gadolinium-based contrast agent	Magnetic resonance imaging	gadodiamide, gadoteridol
gadoxetate	Requip XL
regadenoson	Lexiscan	adenosine receptor agonist	Pharmacologic stress agent for radionuclide myocardial perfusion imaging	adenosine	page 917
rilonacept (also known as IL-1 Trap)	Arcalyst	interleukin-1 blocker	Treatment of cryopyrin-associated periodic syndromes, including Familial Cold Autoinflammatory Syndrome and Muckle-Wells Syndrome	anakinra	page 672
silodosin	Rapaflo	alpha-1 adrenergic receptor antagonist	Treatment of benign prostatic hyperplasia	prazosin, terazosin, doxazosin, tamsulosin, alfuzosin	pages 269-271
tapentadol	none	m-opioid receptor agonist & norepinephrine reuptake inhibittor	Relief of pain	tramadol	page 566
tetrabenazine	Xenazine	monoamine depletor	Treatment of chorea associated with Huntington´s disease	reserpine	pages 173, 541