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Thursday, March 12, 2009

Drugs Licensed in 2008 With Mechanisms Similar to Previously Approved Drugs

Generic NameBrand NamePharmacology2008 FDA Approved IndicationPharmacologically Similar Agents11th Edition Reference
bendamustineTreandaalkylating agentTreatment of chronic lymphocytic leukemiabusulfan, carmustine, chlorambucil, cyclophosphamide, ifosfamide, melphalanpages 1322-1327
certolizumabCimziatumor necrosis factor inhibitorManagement of Chron's diseaseinfliximabpage 1419
clevidipineCleviprexdihydropyridine calcium channel antagonistTreatment of hypertensionamlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine nisoldipinepages 832-838, 857-858
degarelixnoneGnRH receptor antagonistTreatment of prostate cancergoserelin, histrelin, leuprolide, triptorelinpages 1387-1388
desvenlafaxine (major metabolite of venlafaxine)Pristiqselective serotonin and norepinephrine reuptake inhibitorTreatment of major depressive disordervenlafaxinepages 434t, 437t, 439t, 444t,
difluprednateDurezolopthalmic corticosteroidTreatment of ocular inflammationprednisolonepages 1724-1725
ethinyl estradiol/levonorgestrelLoSeasoniqueoral contraceptivePrevention of pregnancyethinyl estradiol/levonorgestrel (Seasonique)pages 1563-1567
etravirineIntelencenon-nucleoside reverse transcriptase inhibitorTreatment of HIV-1 infectiondelavridine, efavirenz, nevirapinepages 1292-1297
fesoterodineToviazmuscarinic receptor antagonistTreatment of overactive bladderdarifenacin, solifenacin, tolterodinepages 173-174
fosaprepitant (produrg of aprepitant)Emendsubstance P/neurokinin 1 receptor antagonistPrevention of nausea and vomiting associated with emetogenic cancer chemotherapyaprepitantpages 1005
fospropofol (produrg of propofol)Lusedrasedative-hypnoticMonitored anesthesia care sedationpropofolpages 350-351
gadofosvesetVasovistgadolinium-based contrast agentMagnetic resonance imaginggadodiamide, gadoteridol 
gadoxetateRequip XL
regadenosonLexiscanadenosine receptor agonistPharmacologic stress agent for radionuclide myocardial perfusion imagingadenosinepage 917
rilonacept (also known as IL-1 Trap)Arcalystinterleukin-1 blockerTreatment of cryopyrin-associated periodic syndromes, including Familial Cold Autoinflammatory Syndrome and Muckle-Wells Syndromeanakinrapage 672
silodosinRapafloalpha-1 adrenergic receptor antagonistTreatment of benign prostatic hyperplasiaprazosin, terazosin, doxazosin, tamsulosin, alfuzosinpages 269-271
tapentadolnonem-opioid receptor agonist & norepinephrine reuptake inhibittorRelief of paintramadolpage 566
tetrabenazineXenazinemonoamine depletorTreatment of chorea associated with Huntington´s diseasereserpinepages 173, 541

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