Wednesday, October 15, 2008

Bilateral Acute Angle Closure Glaucoma in a 50 year old female after Oral Administration of Flavoxate

Case Report published in British Journal of Clinical Pharmacology
Zakir Shaik Mohammed, 1 Zaka-ur-Rab Simi, 1 Salman Mohd Tariq 2 & Khan Rahat Ali 2
1 Institute of Ophthalmology, Aligarh Muslim University, Aligarh 202002 and 2 Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India
DIGITAL OBJECT IDENTIFIER (DOI)10.1111/j.1365-2125.2008.03254.x
PMID: 18754848
Published Online: 8 Jul 2008
A 50 yrs old female presented with sudden painful diminution of vision of both eyes after ingesting a tablet of Flavoxate (200 mg). She was diagnosed as a case of Bilateral Acute Angle Closure Glaucoma (ACG). Intra Ocular Pressure was 69.3 mmHg in both eyes which normalized within ten hours after discontinuation of Flavoxate and administration antiglaucoma drugs. The effect was probably due to anticholinergic activity of Flavoxate leading to narrowing of the angle of the anterior chamber by pupillary dilatation. Naranjo ADR Probability Scale as well as WHO Causality Categories indicated a probable relationship between the adverse effect (Bilateral Acute ACG) and Flavoxate therapy. To the best of our knowledge, this is the first case report of Flavoxate induced Bilateral Acute ACG
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